Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 5/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.44 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.44 |
| ▸ | EPHA8 | P29322 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.44 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.44 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.44 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.43 |
| ▸ | NCF1 | P14598 | 1/20 | 0.43 |
| ▸ | KRAS | P01116 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL359988 | 0.89 | SRC (0.60) | SRCPDGFRBPDGFRAFGFR2EGFR | |
| SCHEMBL29387468 | 0.89 | SRC (0.60) | SRCPDGFRBPDGFRAFGFR2EGFR | |
| SCHEMBL29576504 | 0.89 | SRC (0.60) | SRCPDGFRBPDGFRAFGFR2EGFR | |
| Hydrochloric Acid SCHEMBL6432173 | 0.88 | SRC (0.58) | SRCPDGFRBPDGFRAFGFR2EGFR | |
| SCHEMBL25239127 | 0.87 | SRC (0.50) | SRCPDGFRBPDGFRAFGFR2EGFR | |
| SCHEMBL6004164 | 0.81 | CGAS (0.59) | SRCPDGFRBPDGFRAEGFRBMPR1B | |
| SCHEMBL24008989 | 0.81 | SRC (0.58) | SRCPDGFRBPDGFRAEGFRBMPR1B | |
| SCHEMBL4499366 | 0.81 | ENPP1 (0.62) | SRCPDGFRBPDGFRAEGFRBMPR1B | |
| SCHEMBL31457635 | 0.81 | SRC (0.52) | SRCPDGFRBPDGFRAEGFRBMPR1B | |
| SCHEMBL22441533 | 0.81 | SRC (0.52) | SRCPDGFRBPDGFRAEGFRBMPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |