Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | MGLL | Q99685 | 2/20 | 0.43 |
| ▸ | HRH2 | P25021 | 6/20 | 0.39 |
| ▸ | HRH1 | P35367 | 6/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD5 | P21918 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3126044 | 0.85 | KCNH2 (0.45) | KCNH2HRH3CCR3CD274DRD2 | |
| SCHEMBL2966847 | 0.83 | KCNH2 (0.46) | KCNH2CCR3PKMCD274DRD2 | |
| SCHEMBL2967483 | 0.81 | KCNH2 (0.48) | KCNH2HRH2HRH1HRH3CCR3 | |
| SCHEMBL2962910 | 0.80 | KCNH2 (0.41) | KCNH2HRH2HRH1HRH3CCR3 | |
| SCHEMBL2966214 | 0.80 | KCNH2 (0.44) | KCNH2HRH2HRH1CCR3PKM | |
| SCHEMBL2967583 | 0.79 | KCNH2 (0.45) | KCNH2HRH2HRH1CCR3PKM | |
| SCHEMBL2963123 | 0.79 | KCNH2 (0.56) | KCNH2HRH2HRH1HRH3CACNA1B | |
| SCHEMBL2966852 | 0.79 | KCNH2 (0.44) | KCNH2HRH2HRH1CCR3KCNA5 | |
| SCHEMBL2961502 | 0.78 | KCNH2 (0.46) | KCNH2HRH2HRH1HRH3CCR3 | |
| SCHEMBL2961112 | 0.78 | KCNH2 (0.43) | KCNH2HRH2HRH1HRH3CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1389212-B1 | 3,7-DIAZABICYCLO 3.3.1| FORMULATIONS AS ANTI-ARRYTHMIC COMPOUNDS | ASTRAZENECA AB (SE) | 2006-07-12 | — | — | EP | disclosed |
| EP-1389212-A1 | 3,7-DIAZABICYCLO 3.3.1] FORMULATIONS AS ANTI-ARRYTHMIC COMPOUNDS | AstraZeneca AB (SE) | 2004-02-18 | — | — | EP | disclosed |