Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 12/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 10/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 10/20 | 0.43 |
| ▸ | HTR3A | P46098 | 2/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6007298 | 0.87 | CHRNA7 (0.41) | CHRNA7CHRNB2CHRNA4HTR3A | |
| SCHEMBL6008210 | 0.82 | CHRNA7 (0.52) | CHRNA7HTR3A | |
| SCHEMBL6009086 | 0.81 | CHRNA7 (0.43) | CHRNA7CHRNB2CHRNA4HTR3A | |
| SCHEMBL6005285 | 0.81 | CHRNA7 (0.42) | CHRNA7CHRNB2CHRNA4HTR3A | |
| SCHEMBL6008771 | 0.81 | CHRNA7 (0.43) | CHRNA7CHRNB2CHRNA4HTR3A | |
| SCHEMBL6007183 | 0.81 | CHRNA7 (0.43) | CHRNA7CHRNB2CHRNA4HTR3A | |
| SCHEMBL6009001 | 0.81 | CHRNA7 (0.43) | CHRNA7CHRNB2CHRNA4HTR3A | |
| SCHEMBL6008636 | 0.80 | CHRNA7 (0.42) | CHRNA7CHRNB2CHRNA4HTR3A | |
| SCHEMBL6008999 | 0.80 | CHRNA7 (0.42) | CHRNA7CHRNB2CHRNA4HTR3A | |
| SCHEMBL6008711 | 0.80 | CHRNA7 (0.42) | CHRNA7CHRNB2CHRNA4HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030045540-A1 | Quinuclidines-substituted-multi-cyclic-heteroaryls for the treatment of disease | PHARMACIA & UPJOHN COMPANY | 2003-03-06 | — | — | US | claimed |
| US-7067515-B2 | Quinuclidines-substituted-multi-cyclic-heteroaryls for the treatment of disease | PFIZER INC. (US) | 2006-06-27 | — | — | US | disclosed |
| US-20030045540-A1 | Quinuclidines-substituted-multi-cyclic-heteroaryls for the treatment of disease | PHARMACIA & UPJOHN COMPANY | 2003-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030045540-A1 | Quinuclidines-substituted-multi-cyclic-heteroaryls for the treatment of disease | NQO2, SLC10A1, CYP7A1 | CHRNA7 594/4885CHRNB2 1185/4885CHRNA4 1450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.