Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 11/20 | 0.66 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.65 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.65 |
| ▸ | POLA1 | P09884 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14185442 | 1.00 | PTGS1 (0.66) | PTGS1NR1H3PTPN1POLA1 | |
| SCHEMBL14286808 | 0.92 | PTGS1 (0.78) | PTGS1NR1H3PTPN1 | |
| SCHEMBL12450155 | 0.92 | PTGS1 (0.78) | PTGS1NR1H3PTPN1 | |
| SCHEMBL267279 | 0.92 | PTGS1 (0.78) | PTGS1NR1H3PTPN1 | |
| SCHEMBL280111 | 0.85 | PTGS1 (0.55) | PTGS1NR1H3PTPN1POLA1 | |
| SCHEMBL12704605 | 0.85 | PTGS1 (0.55) | PTGS1NR1H3PTPN1POLA1 | |
| SCHEMBL12704610 | 0.83 | PTGS1 (0.64) | PTGS1NR1H3PTPN1 | |
| SCHEMBL280043 | 0.83 | PTGS1 (0.64) | PTGS1NR1H3PTPN1 | |
| SCHEMBL280494 | 0.83 | PTGS1 (0.64) | PTGS1NR1H3PTPN1 | |
| SCHEMBL280487 | 0.83 | PTGS1 (0.64) | PTGS1NR1H3PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912932-B1 | INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-A MODULATORS; SYNTHESES OF SUCH MODULATORS AND METHODS OF USING SUCH MODULATORS | NEREUS PHARMACEUTICALS INC (US) | 2012-05-02 | — | — | EP | disclosed |