Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL330524 | 0.85 | SMN1; SMN2 (0.40) | SMN1; SMN2POLBHTTALDH1A1 | |
| SCHEMBL4039997 | 0.84 | POLB (0.44) | SMN1; SMN2POLBHTTMAPTALDH1A1 | |
| SCHEMBL10917161 | 0.79 | SMN1; SMN2 (0.55) | SMN1; SMN2POLBHTTMAPTALDH1A1 | |
| SCHEMBL28262270 | 0.77 | SMN1; SMN2 (0.47) | SMN1; SMN2POLBHTTMAPTALDH1A1 | |
| SCHEMBL10733902 | 0.76 | MAPT (0.56) | SMN1; SMN2POLBHTTMAPTALDH1A1 | |
| SCHEMBL331457 | 0.75 | MEN1 (0.36) | SMN1; SMN2POLBHTTALDH1A1 | |
| SCHEMBL1527735 | 0.75 | SMN1; SMN2 (0.51) | SMN1; SMN2POLBMAPTALDH1A1PKM | |
| SCHEMBL10918765 | 0.74 | SMN1; SMN2 (0.43) | SMN1; SMN2POLBHTTMAPTALDH1A1 | |
| SCHEMBL331072 | 0.73 | CYP1A2 (0.32) | SMN1; SMN2 | |
| SCHEMBL14395362 | 0.73 | SMN1; SMN2 (0.43) | SMN1; SMN2POLBHTTMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689751-A1 | 5,7-DIAMINOPYRAZOLO¬4,3-D|PYRIMIDINES WITH PDE-5 INHIBITING ACTIVITY | Pfizer Limited (GB) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005049616-A1 | 5,7-DIAMINOPYRAZOLO [4,3-d] PYRIMIDINES WITH PDE-5 INHIBITING ACTIVITY | PFIZER LIMITED (GB) | 2005-06-02 | — | — | WO | disclosed |