Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PDE8B | O95263 | 11/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL332338 | 0.85 | PDE8B (0.41) | GAAPDE8BKMT2APOLBLMNA | |
| SCHEMBL10733902 | 0.74 | MAPT (0.56) | KMT2AHTTPOLBSMN1; SMN2LMNA | |
| SCHEMBL1810376 | 0.72 | HPGD (0.40) | GAAHTTPOLBSMN1; SMN2 | |
| SCHEMBL10917161 | 0.72 | SMN1; SMN2 (0.55) | KMT2AHTTPOLBSMN1; SMN2LMNA | |
| SCHEMBL23880176 | 0.71 | PDE8B (0.42) | GAAPDE8BKMT2APOLBLMNA | |
| SCHEMBL28262270 | 0.71 | SMN1; SMN2 (0.47) | KMT2AHTTPOLBSMN1; SMN2LMNA | |
| SCHEMBL10918765 | 0.70 | SMN1; SMN2 (0.43) | KMT2AHTTPOLBSMN1; SMN2LMNA | |
| SCHEMBL5414653 | 0.70 | POLB (0.41) | KMT2AHTTPOLBSMN1; SMN2LMNA | |
| SCHEMBL6629463 | 0.69 | SMN1; SMN2 (0.49) | SMN1; SMN2 | |
| SCHEMBL30141552 | 0.69 | PDE8B (0.43) | GAAPDE8BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689751-A1 | 5,7-DIAMINOPYRAZOLO¬4,3-D|PYRIMIDINES WITH PDE-5 INHIBITING ACTIVITY | Pfizer Limited (GB) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005049616-A1 | 5,7-DIAMINOPYRAZOLO [4,3-d] PYRIMIDINES WITH PDE-5 INHIBITING ACTIVITY | PFIZER LIMITED (GB) | 2005-06-02 | — | — | WO | disclosed |