Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 11/20 | 0.55 |
| ▸ | PSEN2 | P49810 | 11/20 | 0.55 |
| ▸ | APH1B | Q8WW43 | 11/20 | 0.55 |
| ▸ | NCSTN | Q92542 | 11/20 | 0.55 |
| ▸ | APH1A | Q96BI3 | 11/20 | 0.55 |
| ▸ | PSENEN | Q9NZ42 | 11/20 | 0.55 |
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.52 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6010530 | 0.85 | UGT1A1 (0.55) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6010279 | 0.85 | UGT1A1 (0.55) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2434946 | 0.82 | PSEN1 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3804911 | 0.79 | KLK5 (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL10788604 | 0.79 | KLK5 (0.64) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9395131 | 0.78 | KLK5 (0.62) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7398543 | 0.78 | KLK5 (0.62) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4036632 | 0.78 | KLK5 (0.62) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL21986636 | 0.78 | KLK5 (0.62) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4038412 | 0.78 | KLK5 (0.62) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697344-A2 | HIV PROTEASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005058841-A2 | HIV PROTEASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 2005-06-30 | — | — | WO | disclosed |