Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.57 |
| ▸ | APP | P05067 | 5/20 | 0.53 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.52 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.52 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.52 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.52 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.52 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.52 |
| ▸ | CTSS | P25774 | 2/20 | 0.52 |
| ▸ | CTSL | P07711 | 1/20 | 0.52 |
| ▸ | CTSB | P07858 | 1/20 | 0.52 |
| ▸ | CTSK | P43235 | 1/20 | 0.52 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | REN | P00797 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3799997 | 1.00 | ATM (0.60) | ATMKLK5APPPSEN1PSEN2 | |
| SCHEMBL3799999 | 1.00 | ATM (0.60) | ATMKLK5APPPSEN1PSEN2 | |
| SCHEMBL7301095 | 0.95 | ATM (0.62) | ATMKLK5APPPSEN1PSEN2 | |
| SCHEMBL7270247 | 0.95 | ATM (0.62) | ATMKLK5APPPSEN1PSEN2 | |
| SCHEMBL7299571 | 0.95 | ATM (0.62) | ATMKLK5APPPSEN1PSEN2 | |
| SCHEMBL7305946 | 0.95 | ATM (0.62) | ATMKLK5APPPSEN1PSEN2 | |
| SCHEMBL3805577 | 0.94 | ATM (0.55) | ATMKLK5APPPSEN1PSEN2 | |
| SCHEMBL3805582 | 0.94 | ATM (0.55) | ATMKLK5APPPSEN1PSEN2 | |
| SCHEMBL3800024 | 0.90 | CYP3A4 (0.56) | ATMKLK5APPPSEN1PSEN2 | |
| SCHEMBL3798830 | 0.90 | CYP3A4 (0.56) | ATMKLK5APPPSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697344-A2 | HIV PROTEASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005058841-A2 | HIV PROTEASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 2005-06-30 | — | — | WO | disclosed |