Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | XBP1 | P17861 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3034787 | 0.96 | SMN1; SMN2 (0.60) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL3045463 | 0.84 | MAPT (0.56) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL5561958 | 0.84 | SMN1; SMN2 (0.63) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL31093984 | 0.84 | SMN1; SMN2 (0.63) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL5133570 | 0.82 | SMN1; SMN2 (0.62) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL963688 | 0.82 | SMN1; SMN2 (0.62) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL28733093 | 0.82 | MAPT (0.60) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL23733551 | 0.81 | SMN1; SMN2 (0.60) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL12251335 | 0.81 | SMN1; SMN2 (0.60) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL19638131 | 0.81 | SMN1; SMN2 (0.60) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1626964-A2 | NEW BENZIMIDAZOLE DERIVATIVES | AstraZeneca AB (SE) | 2006-02-22 | — | — | EP | disclosed |
| WO-2004100865-A2 | NEW BENZIMIDAZOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2004-11-25 | — | — | WO | disclosed |