⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4031160 | 1.00 | — | — | |
| SCHEMBL9813090 | 0.79 | MAPK1 (0.38) | — | |
| SCHEMBL1454344 | 0.73 | — | — | |
| SCHEMBL8378655 | 0.72 | — | — | |
| SCHEMBL8047034 | 0.72 | — | — | |
| SCHEMBL964277 | 0.71 | — | — | |
| SCHEMBL1227367 | 0.71 | — | — | |
| SCHEMBL5076455 | 0.71 | — | — | |
| SCHEMBL749845 | 0.71 | — | — | |
| SCHEMBL3099341 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160361356-A1 | METHODS, COMPOSITIONS AND ARTICLES OF MANUFACTURE FOR ENHANCING SURVIVABILITY OF CELLS, TISSUES, ORGANS, AND ORGANISMS | FRED HUTCHINSON CANCER RESEARCH CENTER | 2016-12-15 | — | — | US | disclosed |
| US-8822535-B2 | Methods, compositions and articles of manufacture for enhancing survivability of cells, tissues, organs, and organisms | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2014-09-02 | — | — | US | disclosed |
| EP-1879599-B1 | METHODS, COMPOSITIONS AND ARTICLES OF MANUFACTURE FOR ENHANCING SURVIVABILITY OF CELLS, TISSUES, ORGANS, AND ORGANISMS | HUTCHINSON FRED CANCER RES (US) | 2013-10-16 | — | — | EP | disclosed |
| US-20120282353-A1 | METHODS, COMPOSITIONS AND ARTICLES OF MANUFACTURE FOR HIF MODULATING COMPOUNDS | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2012-11-08 | — | — | US | disclosed |
| US-20120135091-A1 | METHODS AND COMPOSITIONS FOR ENHANCING LIFESPAN INVOLVING SIRTUIN-MODULATING COMPOUNDS AND CHALCOGENIDES | US ARMY, SECRETARY OF THE ARMY | 2012-05-31 | — | — | US | disclosed |
| US-20120040024-A1 | METHODS AND COMPOSITIONS FOR ENHANCING SURVIVABILITY OF CELLS, TISSUES, ORGANS AND ORGANISMS | FRED HUTCHISON CANCER RESEARCH CENTER | 2012-02-16 | — | — | US | disclosed |
| WO-2008040002-A9 | METHODS, COMPOSITIONS AND ARTICLES OF MANUFACTURE FOR HIF MODULATING COMPOUNDS | HUTCHINSON FRED CANCER RES (US) | 2009-04-16 | — | — | WO | disclosed |
| US-20090011051-A1 | Methods, Compositions and Articles of Manufacture for HIF Modulating Compounds | FRED HUTCHINSON CANCER RESEARCH CENTER | 2009-01-08 | — | — | US | disclosed |
| US-20080226750-A1 | Methods, Compositions and Articles of Manufacture for Treating Shock and Other Adverse Conditions | FRED HUTCHINSON CANCER RESEARCH CENTER | 2008-09-18 | — | — | US | disclosed |
| WO-2008089439-A2 | METHODS AND COMPOSITIONS FOR ENHANCING LIFESPAN INVOLVING SIRTUIN-MODULATING COMPOUNDS AND CHALCOGENIDES | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2008-07-24 | — | — | WO | disclosed |
| US-20080171726-A1 | oxygen antagonists; reducing agent, preservatives; enhancing survivability and achieving stasis or pre-stasis in biological materials (cells, tissues); organ transplantation, hyperthermia, wound healing, hemorrhagic shock, cardioplegia for bypass surgery, neurodegeneration, hypothermia, and cancer | ROTH MARK B | 2008-07-17 | — | — | US | disclosed |
| US-20080171725-A1 | Oxygen antagonists; reducing agent, preservatives; enhancing survivability and achieving stasis or pre-stasis in cells or tissues; organ transplantation, hyperthermia, wound healing, hemorrhagic shock, cardioplegia for bypass surgery, neurodegeneration, hypothermia, and cancer | ROTH MARK B | 2008-07-17 | — | — | US | disclosed |
| WO-2008040002-A2 | METHODS, COMPOSITIONS AND ARTICLES OF MANUFACTURE FOR HIF MODULATING COMPOUNDS | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2008-04-03 | — | — | WO | disclosed |
| EP-1879599-A2 | METHODS, COMPOSITIONS AND ARTICLES OF MANUFACTURE FOR ENHANCING SURVIVABILITY OF CELLS, TISSUES, ORGANS, AND ORGANISMS | Fred Hutchinson Cancer Research Center (US) | 2008-01-23 | — | — | EP | disclosed |
| US-20070265223-A1 | COMPOSITIONS AND METHODS OF ENHANCING SURVIVABILITY AND REDUCING INJURY OF CELLS, TISSUES, ORGANS, AND ORGANISMS UNDER HYPOXIC OR ISCHEMIC CONDITIONS | IKARIA, INC. (US) | 2007-11-15 | — | — | US | disclosed |
| WO-2007124447-A2 | USE OF CHALCOGENIDES FOR TREATING SHOCK AND OTHER ADVERSE CONDITIONS | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2007-11-01 | — | — | WO | disclosed |
| US-20070078113-A1 | Oxygen antagonists; reducing agent, preservatives; enhancing survivability and achieving stasis or pre-stasis in cells or tissues; organ transplantation, hyperthermia, wound healing, hemorrhagic shock, cardioplegia for bypass surgery, neurodegeneration, hypothermia, and cancer | FRED HUTCHINSON CANCER RESEARCH CENTER | 2007-04-05 | — | — | US | disclosed |
| WO-2006113914-A2 | METHODS, COMPOSITIONS AND ARTICLES OF MANUFACTURE FOR ENHANCING SURVIVABILITY OF CELLS, TISSUES, ORGANS, AND ORGANISMS | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2006-10-26 | — | — | WO | disclosed |