Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.38 |
| ▸ | IDUA | P35475 | 1/20 | 0.36 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 3/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CD69 | Q07108 | 1/20 | 0.33 |
| ▸ | OGA | O60502 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | FGF2 | P09038 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8182208 | 1.00 | PTPN1 (0.38) | PTPN1IDUASUCNR1CA9CA12 | |
| SCHEMBL7053556 | 0.83 | PTPN1 (0.49) | PTPN1SUCNR1CA9CA12CA1 | |
| SCHEMBL4579988 | 0.83 | PTPN1 (0.49) | PTPN1SUCNR1CA9CA12CA1 | |
| SCHEMBL5674524 | 0.83 | PTPN1 (0.49) | PTPN1SUCNR1CA9CA12CA1 | |
| SCHEMBL24853896 | 0.81 | IDUA (0.38) | IDUASUCNR1FGF2AKT1 | |
| SCHEMBL7115623 | 0.81 | IDUA (0.38) | IDUASUCNR1FGF2AKT1 | |
| SCHEMBL2353880 | 0.81 | IDUA (0.38) | IDUASUCNR1FGF2AKT1 | |
| SCHEMBL29775119 | 0.79 | IDUA (0.39) | IDUASUCNR1FGF2 | |
| SCHEMBL9796069 | 0.77 | CA9 (0.39) | CA9CA12CA1CA2CD69 | |
| SCHEMBL15975969 | 0.77 | CA9 (0.39) | CA9CA12CA1CA2CD69 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1699760-A2 | ANTI-HYPERCHOLESTEROLEMIC COMPOUNDS | Merck & Co., Inc. (US) | 2006-09-13 | — | — | EP | disclosed |
| WO-2005062824-A2 | ANTI-HYPERCHOLESTEROLEMIC COMPOUNDS | MERCK & CO., INC. (US) | 2005-07-14 | — | — | WO | disclosed |