Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.67 |
| ▸ | FLT1 | P17948 | 3/20 | 0.48 |
| ▸ | ABL1 | P00519 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | CSF1R | P07333 | 2/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.48 |
| ▸ | KIT | P10721 | 2/20 | 0.48 |
| ▸ | FLT4 | P35916 | 2/20 | 0.48 |
| ▸ | RET | P07949 | 2/20 | 0.48 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.48 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.48 |
| ▸ | CIT | O14578 | 1/20 | 0.48 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | STK10 | O94804 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | YES1 | P07947 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL186584 | 1.00 | KDR (0.67) | KDRFLT1ABL1EGFRCSF1R | |
| SCHEMBL6105084 | 0.94 | KDR (0.58) | KDRFLT1ABL1EGFRCSF1R | |
| SCHEMBL6103204 | 0.94 | KDR (0.58) | KDRFLT1ABL1EGFRCSF1R | |
| SCHEMBL446128 | 0.90 | KDR (0.53) | KDRFLT1ABL1EGFRCSF1R | |
| SCHEMBL186234 | 0.86 | KDR (0.71) | KDRFLT1ABL1EGFRCSF1R | |
| SCHEMBL6225912 | 0.85 | KDR (0.63) | KDRFLT1ABL1EGFRCSF1R | |
| SCHEMBL6013581 | 0.85 | KDR (0.63) | KDRFLT1ABL1EGFRCSF1R | |
| SCHEMBL447671 | 0.85 | KDR (0.60) | KDRFLT1ABL1EGFRCSF1R | |
| SCHEMBL6267580 | 0.85 | KDR (0.60) | KDRFLT1ABL1EGFRCSF1R | |
| SCHEMBL3146966 | 0.84 | KDR (0.57) | KDRFLT1ABL1EGFRCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6995162-B2 | Substituted alkylamine derivatives and methods of use | AMGEN INC. (US) | 2006-02-07 | — | — | US | claimed |