Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 4/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | GPR18 | Q14330 | 2/20 | 0.33 |
| ▸ | PRKDC | P78527 | 2/20 | 0.33 |
| ▸ | PLAT | P00750 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | XBP1 | P17861 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2462756 | 0.80 | GRM5 (0.41) | GRM5IGF1RBRD4CREBBPPRKDC | |
| SCHEMBL2458295 | 0.77 | IGF1R (0.38) | GRM5IGF1RBRD4CREBBPPLAT | |
| SCHEMBL2460398 | 0.74 | MAOB (0.41) | IGF1RPRKDCBACE1 | |
| SCHEMBL2457017 | 0.74 | MAOB (0.39) | IGF1RBRD4PRKDCALDH1A1HPGD | |
| SCHEMBL3537072 | 0.74 | MAOB (0.40) | IGF1RPRKDCALDH1A1KMT2ANPSR1 | |
| SCHEMBL2460772 | 0.73 | GRM5 (0.34) | GRM5IGF1RPRKDCALDH1A1HPGD | |
| SCHEMBL2460471 | 0.73 | IGF1R (0.42) | IGF1RNAAA | |
| SCHEMBL2457734 | 0.73 | NR1H2 (0.41) | IGF1RPRKDCALDH1A1HPGDXBP1 | |
| SCHEMBL3537676 | 0.72 | MRGPRX4 (0.42) | — | |
| SCHEMBL2458332 | 0.72 | NR1H2 (0.39) | IGF1RPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675860-A2 | IMIDAZO[1,5-A]PYRAZINE TYROSINE KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005037836-A2 | IMIDAZO ‘1, 5 - A ! PYRAZINE TYROSINE KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2005-04-28 | — | — | WO | disclosed |