Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 15/20 | 1.00 |
| ▸ | GSK3A | P49840 | 8/20 | 1.00 |
| ▸ | PRKCA | P17252 | 3/20 | 0.57 |
| ▸ | RGS4 | P49798 | 4/20 | 0.48 |
| ▸ | RGS8 | P57771 | 4/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3382652 | 0.84 | GSK3B (0.73) | GSK3BGSK3APRKCARGS4RGS8 | |
| SCHEMBL3384015 | 0.83 | GSK3B (0.71) | GSK3BGSK3APRKCARGS4RGS8 | |
| SCHEMBL3383895 | 0.80 | GSK3B (0.67) | GSK3BGSK3APRKCARGS4RGS8 | |
| SCHEMBL3384189 | 0.79 | GSK3B (0.66) | GSK3BGSK3APRKCARGS4RGS8 | |
| SCHEMBL3380240 | 0.78 | GSK3B (1.00) | GSK3BGSK3APRKCARGS4RGS8 | |
| SCHEMBL3384007 | 0.76 | GSK3B (1.00) | GSK3BGSK3APGR | |
| Krm-7777 SCHEMBL3384141 | 0.72 | GSK3B (1.00) | GSK3BGSK3APRKCARGS4RGS8 | |
| SCHEMBL3383820 | 0.70 | GSK3B (0.72) | GSK3BGSK3APRKCARGS4RGS8 | |
| SCHEMBL16042316 | 0.67 | GSK3B (0.68) | GSK3BGSK3APRKCARGS4RGS8 | |
| SCHEMBL6428260 | 0.67 | GSK3B (0.80) | GSK3BGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006045581-A1 | THE USE OF 1, 2, 4-THIADIAZOLIDINE-3, 5-DIONES AS PPAR ACTIVATORS | NEUROPHARMA, S.A. (ES) | 2006-05-04 | — | — | WO | claimed |
| WO-2006045581-A1 | THE USE OF 1, 2, 4-THIADIAZOLIDINE-3, 5-DIONES AS PPAR ACTIVATORS | NEUROPHARMA, S.A. (ES) | 2006-05-04 | — | — | WO | disclosed |
| WO-2006045581-A1 | THE USE OF 1, 2, 4-THIADIAZOLIDINE-3, 5-DIONES AS PPAR ACTIVATORS | NEUROPHARMA, S.A. (ES) | 2006-05-04 | — | — | WO | disclosed |