Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 20/20 | 0.61 |
| ▸ | CDK2AP1 | O14519 | 5/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5556370 | 1.00 | CHEK1 (0.61) | CHEK1CDK2AP1 | |
| SCHEMBL1564542 | 0.87 | CHEK1 (0.79) | CHEK1CDK2AP1 | |
| SCHEMBL1564548 | 0.87 | CHEK1 (0.79) | CHEK1CDK2AP1 | |
| SCHEMBL1562842 | 0.81 | CHEK1 (0.56) | CHEK1CDK2AP1 | |
| SCHEMBL5554681 | 0.79 | CHEK1 (0.76) | CHEK1CDK2AP1 | |
| SCHEMBL1563818 | 0.79 | CHEK1 (0.82) | CHEK1CDK2AP1 | |
| SCHEMBL1563815 | 0.79 | CHEK1 (0.82) | CHEK1CDK2AP1 | |
| SCHEMBL1564480 | 0.79 | CHEK1 (0.82) | CHEK1CDK2AP1 | |
| SCHEMBL1564950 | 0.77 | CHEK1 (0.72) | CHEK1CDK2AP1 | |
| SCHEMBL1564946 | 0.77 | CHEK1 (0.72) | CHEK1CDK2AP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732920-A2 | THIOPHENE DERIVATIVES AS CHK 1 INHIBITORS | AstraZeneca AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005066163-A2 | THIOPHENE DERIVATIVES AS CHK 1 INIHIBITORS | ASTRAZENECA AB (SE) | 2005-07-21 | — | — | WO | disclosed |