Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.40 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.40 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6016621 | 0.91 | MAPT (0.47) | MAPTKDM4EPOLBKMT2AALDH1A1 | |
| SCHEMBL21768226 | 0.81 | KDM4E (0.52) | MAPTKDM4EPOLBKMT2AALDH1A1 | |
| SCHEMBL2418244 | 0.81 | TNF (0.44) | MAPTKDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL11412098 | 0.79 | CNR2 (0.48) | MAPTKDM4EPOLBKMT2AALDH1A1 | |
| SCHEMBL13122708 | 0.79 | MAPT (0.50) | MAPTKDM4EPOLBKMT2AALDH1A1 | |
| SCHEMBL6016433 | 0.79 | SMN1; SMN2 (0.49) | MAPTPOLBKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL15229763 | 0.78 | KDM4E (0.58) | MAPTKDM4EPOLBALDH1A1RAB9A | |
| SCHEMBL31133377 | 0.78 | KDM4E (0.58) | MAPTKDM4EPOLBALDH1A1RAB9A | |
| SCHEMBL1489156 | 0.76 | MAPT (0.47) | MAPTPOLBKMT2ALMNACYP1A2 | |
| SCHEMBL28307941 | 0.75 | KDM4E (0.68) | MAPTKDM4EPOLBKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1471915-A4 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS INC (US) | 2006-02-15 | — | — | EP | disclosed |
| EP-1471915-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | Rigel Pharmaceuticals, Inc. (US) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003063794-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2003-08-07 | — | — | WO | disclosed |