SCHEMBL6016334

SCHEMBL6016334

COC(=O)Cc1n[nH]c2ccc(Nc3ncc(F)c(Nc4cccc(O)c4)n3)cc12

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SYK P43405 18/20 0.59
AURKA O14965 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6016391 1.00 SYK (0.59) SYKAURKA
SCHEMBL6016383 0.93 SYK (0.59) SYKAURKA
SCHEMBL6016125 0.93 SYK (0.59) SYKAURKA
SCHEMBL6016262 0.86 SYK (0.63) SYK
SCHEMBL6016765 0.85 SYK (0.63) SYKAURKA
SCHEMBL6016269 0.85 SYK (0.63) SYKAURKA
SCHEMBL6016477 0.85 SYK (0.59) SYKAURKA
SCHEMBL6016153 0.85 SYK (0.59) SYKAURKA
SCHEMBL6016710 0.85 SYK (0.62) SYKAURKA
SCHEMBL6016285 0.84 SYK (0.59) SYK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1471915-A4 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES RIGEL PHARMACEUTICALS INC (US) 2006-02-15 EP disclosed
EP-1471915-A2 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES Rigel Pharmaceuticals, Inc. (US) 2004-11-03 EP disclosed
WO-2003063794-A2 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES RIGEL PHARMACEUTICALS, INC. (US) 2003-08-07 WO disclosed