Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 13/20 | 0.67 |
| ▸ | EGFR | P00533 | 6/20 | 0.54 |
| ▸ | ITK | Q08881 | 5/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3836148 | 0.87 | SYK (0.73) | SYKEGFRITKAURKA | |
| SCHEMBL657949 | 0.84 | SYK (0.67) | SYKEGFRITKAURKA | |
| SCHEMBL654417 | 0.84 | SYK (0.67) | SYKEGFRITKAURKA | |
| SCHEMBL656819 | 0.81 | SYK (0.79) | SYKEGFRITKAURKA | |
| SCHEMBL654783 | 0.78 | SYK (0.78) | SYKEGFRITKAURKA | |
| SCHEMBL657950 | 0.78 | SYK (0.68) | SYKEGFRAURKA | |
| SCHEMBL654418 | 0.78 | SYK (0.68) | SYKEGFRAURKA | |
| SCHEMBL655466 | 0.78 | SYK (1.00) | SYKITKAURKA | |
| SCHEMBL656035 | 0.77 | SYK (0.73) | SYKEGFRITKAURKA | |
| SCHEMBL655791 | 0.77 | SYK (0.67) | SYKAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1471915-A4 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS INC (US) | 2006-02-15 | — | — | EP | disclosed |
| EP-1471915-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | Rigel Pharmaceuticals, Inc. (US) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003063794-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2003-08-07 | — | — | WO | disclosed |