Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | GSK3B | P49841 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | AXL | P30530 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | BCR | P11274 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6016427 | 0.89 | SMN1; SMN2 (0.53) | SMN1; SMN2GSK3BMAPTAXLALDH1A1 | |
| SCHEMBL14564361 | 0.84 | SMN1; SMN2 (0.55) | SMN1; SMN2GSK3BMAPTALDH1A1CYP1A2 | |
| SCHEMBL22267604 | 0.83 | GSK3B (0.55) | SMN1; SMN2GSK3BMAPTMAP2K4 | |
| SCHEMBL4300704 | 0.80 | SMN1; SMN2 (0.71) | SMN1; SMN2MAPTALDH1A1GAA | |
| SCHEMBL6016433 | 0.79 | SMN1; SMN2 (0.49) | SMN1; SMN2GSK3BMAPTALDH1A1CYP1A2 | |
| SCHEMBL2914448 | 0.79 | AXL (0.47) | GSK3BMAPTAXLCHEK1PKM | |
| SCHEMBL2418244 | 0.76 | TNF (0.44) | SMN1; SMN2GSK3BMAPTAXLALDH1A1 | |
| SCHEMBL15372574 | 0.76 | GSK3B (0.44) | SMN1; SMN2GSK3BMAPTAXLALDH1A1 | |
| SCHEMBL16095565 | 0.76 | AXL (0.50) | GSK3BMAPTAXLCHEK1PKM | |
| SCHEMBL14574212 | 0.75 | KDM4E (0.63) | SMN1; SMN2GSK3BMAPTAXLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1471915-A4 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS INC (US) | 2006-02-15 | — | — | EP | disclosed |
| EP-1471915-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | Rigel Pharmaceuticals, Inc. (US) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003063794-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2003-08-07 | — | — | WO | disclosed |