Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.57 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.57 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6016645 | 1.00 | MEN1 (0.57) | MEN1KMT2AMAPTLMNAPLIN1 | |
| SCHEMBL3565282 | 0.85 | MEN1 (0.48) | MEN1KMT2AMAPTLMNAPLIN1 | |
| SCHEMBL3565281 | 0.85 | MEN1 (0.48) | MEN1KMT2AMAPTLMNAPLIN1 | |
| SCHEMBL3570355 | 0.85 | KMT2A (0.50) | MEN1KMT2AMAPTLMNAPLIN1 | |
| SCHEMBL3570354 | 0.85 | KMT2A (0.50) | MEN1KMT2AMAPTLMNAPLIN1 | |
| SCHEMBL30322741 | 0.82 | KMT2A (0.60) | MEN1KMT2AMAPTLMNAPLIN1 | |
| SCHEMBL4589656 | 0.82 | KMT2A (0.60) | MEN1KMT2AMAPTLMNAPLIN1 | |
| SCHEMBL10864261 | 0.82 | MAPT (0.58) | MEN1KMT2AMAPTLMNAPLIN1 | |
| SCHEMBL2953727 | 0.82 | CYP11B1 (0.50) | MEN1KMT2AMAPTLMNAPLIN1 | |
| SCHEMBL2953731 | 0.82 | CYP11B1 (0.50) | MEN1KMT2AMAPTLMNAPLIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187815-B1 | 4-PHENYL-PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2006-02-08 | — | — | EP | disclosed |
| EP-1187815-A1 | 4-PHENYL-PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-20 | — | — | EP | disclosed |
| US-6274588-B1 | NEUROKININ OR SUBSTANCE P ANTAGONISTS; CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDES; ANTIDEPRESSANTS, ANXIOLYTIC AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-14 | — | — | US | disclosed |
| WO-2000073279-A1 | 4-PHENYL-PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-12-07 | — | — | WO | disclosed |