Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 13/20 | 0.69 |
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.50 |
| ▸ | PRMT7 | Q9NVM4 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | ULK1 | O75385 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6016192 | 0.85 | SYK (0.62) | SYKEGFRSTK17AIGF1R | |
| SCHEMBL6016199 | 0.85 | SYK (0.52) | SYKSTK17AIGF1R | |
| SCHEMBL6016559 | 0.84 | SYK (0.64) | SYKEGFRSTK17APRMT7IGF1R | |
| SCHEMBL656467 | 0.84 | SYK (0.79) | SYKEGFRSTK17AULK1 | |
| SCHEMBL31294168 | 0.84 | SYK (0.79) | SYKEGFRSTK17AULK1 | |
| SCHEMBL3857488 | 0.83 | SYK (0.53) | SYKEGFRSTK17AIGF1R | |
| SCHEMBL6016285 | 0.83 | SYK (0.59) | SYKEGFR | |
| SCHEMBL6016642 | 0.83 | SYK (0.64) | SYKEGFR | |
| SCHEMBL6016415 | 0.83 | SYK (0.59) | SYKEGFR | |
| SCHEMBL658160 | 0.82 | SYK (1.00) | SYKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1471915-A4 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS INC (US) | 2006-02-15 | — | — | EP | disclosed |
| EP-1471915-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | Rigel Pharmaceuticals, Inc. (US) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003063794-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2003-08-07 | — | — | WO | disclosed |