Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 15/20 | 0.72 |
| ▸ | AURKA | O14965 | 5/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL655245 | 0.92 | SYK (0.69) | SYKAURKAEGFR | |
| SCHEMBL655142 | 0.84 | SYK (1.00) | SYKAURKA | |
| SCHEMBL657173 | 0.84 | SYK (1.00) | SYKAURKA | |
| SCHEMBL655683 | 0.83 | SYK (0.71) | SYKAURKAEGFR | |
| SCHEMBL657428 | 0.82 | SYK (0.82) | SYKAURKAEGFR | |
| SCHEMBL655491 | 0.80 | SYK (0.75) | SYKAURKAEGFR | |
| SCHEMBL656587 | 0.79 | SYK (0.72) | SYKAURKAEGFR | |
| SCHEMBL21802138 | 0.76 | SYK (0.73) | SYKAURKAEGFR | |
| SCHEMBL658531 | 0.76 | SYK (0.85) | SYKAURKA | |
| SCHEMBL657431 | 0.76 | SYK (0.85) | SYKAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1471915-A4 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS INC (US) | 2006-02-15 | — | — | EP | disclosed |
| EP-1471915-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | Rigel Pharmaceuticals, Inc. (US) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003063794-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2003-08-07 | — | — | WO | disclosed |