Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | PRNP | P04156 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMC2 | O95347 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | SMC1A | Q14683 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.35 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3861246 | 0.82 | EGFR (0.34) | EGFRPKMMEN1KMT2AALDH1A1 | |
| SCHEMBL3859991 | 0.79 | EGFR (0.38) | EGFRPKMMEN1KMT2AALDH1A1 | |
| SCHEMBL6727195 | 0.79 | SRC (0.45) | EGFRPKMMEN1KMT2AALDH1A1 | |
| SCHEMBL27670445 | 0.79 | MAP2K1 (0.42) | EGFRPKMMEN1KMT2AALDH1A1 | |
| SCHEMBL1076189 | 0.79 | MAP2K1 (0.42) | EGFRPKMMEN1KMT2AALDH1A1 | |
| SCHEMBL6016744 | 0.78 | MAP2K1 (0.40) | EGFRPKMMEN1KMT2AALDH1A1 | |
| SCHEMBL1038071 | 0.78 | MAP2K1 (0.45) | EGFRPKMMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL18272624 | 0.77 | MAP2K1 (0.49) | EGFRPKMMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1041272 | 0.77 | IDO1 (0.40) | EGFRPKMMEN1KMT2AALDH1A1 | |
| SCHEMBL19141812 | 0.76 | DPP4 (0.40) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1482932-A4 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS | ARRAY BIOPHARMA INC (US) | 2006-04-05 | — | — | EP | disclosed |
| EP-1482932-A1 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS | Array Biopharma, Inc. (US) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003077914-A1 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS | ARRAY BIOPHARMA, INC (US) | 2003-09-25 | — | — | WO | disclosed |