Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 17/20 | 0.60 |
| ▸ | AURKA | O14965 | 3/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL658892 | 0.86 | SYK (0.65) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL658015 | 0.86 | SYK (0.65) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL657955 | 0.81 | SYK (0.65) | SYKAURKAMAPK8AURKBCDK19 | |
| R-112 SCHEMBL655935 | 0.77 | SYK (1.00) | SYKAURKAMAPK8AURKBCDK19 | |
| R-112 SCHEMBL31294216 | 0.77 | SYK (1.00) | SYKAURKAMAPK8AURKBCDK19 | |
| R-112 SCHEMBL29360016 | 0.77 | SYK (1.00) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL656711 | 0.76 | SYK (0.64) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL16660512 | 0.76 | SYK (0.64) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL657430 | 0.76 | SYK (0.67) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL658530 | 0.76 | SYK (0.67) | SYKAURKAMAPK8AURKBCDK19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1471915-A4 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS INC (US) | 2006-02-15 | — | — | EP | disclosed |
| EP-1471915-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | Rigel Pharmaceuticals, Inc. (US) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003063794-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2003-08-07 | — | — | WO | disclosed |