Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH2 known ✓ | P48735 | 1/20 | 0.44 |
| ▸ | SYK known ✓ | P43405 | 1/20 | 0.34 |
| ▸ | GALR2 | O43603 | 3/20 | 0.38 |
| ▸ | GALR1 | P47211 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | EHMT2 | Q96KQ7 | 3/20 | 0.36 |
| ▸ | EHMT1 | Q9H9B1 | 3/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | ITK | Q08881 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL4829665 | 0.84 | EHMT2 (0.41) | IDH2GALR2GALR1EHMT2EHMT1 | |
| SCHEMBL4840203 | 0.82 | IDH2 (0.49) | IDH2GALR2GALR1EHMT2EHMT1 | |
| SCHEMBL4829410 | 0.82 | IDH2 (0.49) | IDH2GALR2GALR1KDM4EPKM | |
| Citric Acid SCHEMBL6017169 | 0.81 | AURKA (0.38) | IDH2EHMT2EHMT1EGFRBTK | |
| Hydrochloric Acid SCHEMBL5554300 | 0.81 | IDH2 (0.48) | IDH2GALR2GALR1KDM4EPKM | |
| Hydrochloric Acid SCHEMBL5431369 | 0.80 | IDH2 (0.47) | IDH2GALR2GALR1KDM4EPKM | |
| SCHEMBL5029195 | 0.77 | IDH2 (0.57) | IDH2EHMT2EHMT1CTSLCTSB | |
| SCHEMBL14300170 | 0.76 | IDH2 (0.52) | IDH2GALR2GALR1EHMT2EHMT1 | |
| Malonic Acid SCHEMBL4829481 | 0.75 | EHMT2 (0.45) | IDH2GALR2GALR1EHMT2EHMT1 | |
| Succinic Acid SCHEMBL4835600 | 0.74 | EHMT2 (0.44) | IDH2GALR2GALR1EHMT2EHMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132423-B2 | Methods and compositions of novel triazine compounds | REDDY US THERAPEUTICS, INC. (US) | 2006-11-07 | — | — | US | disclosed |