Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 4/20 | 0.38 |
| ▸ | AKT1 | P31749 | 6/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.37 |
| ▸ | AKT1S1 | Q96B36 | 4/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.35 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.35 |
| ▸ | AKT2 | P31751 | 1/20 | 0.35 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6017399 | 0.88 | AKT1 (0.40) | KITAKT1RPS6KB1AKT1S1SIRT2 | |
| SCHEMBL2800727 | 0.72 | AKT1 (0.67) | AKT1AKT1S1AKT2AKT3 | |
| SCHEMBL4255375 | 0.72 | HTR2C (0.44) | KITAKT1RPS6KB1AKT1S1AKT2 | |
| SCHEMBL2552239 | 0.72 | AKT2 (0.41) | AKT1RPS6KB1AKT1S1AKT2AKT3 | |
| SCHEMBL13229915 | 0.72 | AKT1 (0.67) | AKT1AKT1S1AKT2AKT3 | |
| Hydrochloric Acid SCHEMBL6018212 | 0.72 | RPS6KB1 (0.37) | KITAKT1RPS6KB1AKT1S1AKT2 | |
| SCHEMBL2552466 | 0.71 | AKT1 (0.63) | AKT1AKT2AKT3 | |
| SCHEMBL2556845 | 0.71 | AKT1 (0.63) | AKT1AKT2AKT3 | |
| Hydrochloric Acid SCHEMBL6017797 | 0.70 | RPS6KB1 (0.37) | KITAKT1RPS6KB1AKT1S1AKT2 | |
| SCHEMBL13855893 | 0.68 | HTR2C (0.53) | KITAKT1RPS6KB1AKT1S1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1684694-A2 | AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005051304-A2 | AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2005-06-09 | — | — | WO | disclosed |