Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 17/20 | 0.64 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.64 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5559151 | 0.92 | ADORA2A (0.67) | ADORA2AADORA1ADORA2BADORA3MEN1 | |
| SCHEMBL5559771 | 0.90 | ADORA2A (0.68) | ADORA2AADORA1ADORA2BADORA3MEN1 | |
| SCHEMBL5559889 | 0.90 | ADORA2A (0.75) | ADORA2AADORA1ADORA2BADORA3MEN1 | |
| SCHEMBL5565811 | 0.90 | ADORA2A (0.55) | ADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL5560059 | 0.83 | ADORA2A (0.75) | ADORA2AADORA1ADORA2BADORA3MEN1 | |
| SCHEMBL5558477 | 0.83 | ADORA2A (0.75) | ADORA2AADORA1ADORA2BADORA3MEN1 | |
| SCHEMBL5563861 | 0.82 | ADORA2A (0.73) | ADORA2AADORA1ADORA2BADORA3MEN1 | |
| SCHEMBL5565276 | 0.82 | ADORA2A (0.81) | ADORA2AADORA1ADORA2BADORA3MEN1 | |
| SCHEMBL5561524 | 0.82 | ADORA2A (0.62) | ADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL5565119 | 0.81 | ADORA2A (0.69) | ADORA2AADORA1ADORA2BADORA3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670805-A1 | THIAZOLOPYRIDINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005028484-A1 | THIAZOLOPYRIDINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-03-31 | — | — | WO | disclosed |