Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.57 |
| ▸ | GAK | O14976 | 1/20 | 0.57 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5564452 | 0.94 | EGFR (0.61) | EGFRERBB2GAKERBB4 | |
| SCHEMBL5570038 | 0.89 | EGFR (0.70) | EGFRERBB2GAKERBB4 | |
| SCHEMBL5564631 | 0.88 | EGFR (0.57) | EGFRERBB2GAK | |
| SCHEMBL5568894 | 0.86 | EGFR (0.64) | EGFRERBB2GAKERBB4 | |
| SCHEMBL3420740 | 0.83 | EGFR (0.85) | EGFRERBB2GAK | |
| SCHEMBL1446950 | 0.82 | EGFR (0.69) | EGFRERBB2GAKERBB4 | |
| SCHEMBL12743454 | 0.81 | EGFR (0.75) | EGFRERBB2GAKERBB4 | |
| SCHEMBL5569341 | 0.81 | EGFR (0.68) | EGFRERBB2 | |
| SCHEMBL1446460 | 0.80 | EGFR (0.78) | EGFRERBB2GAKERBB4 | |
| SCHEMBL1446379 | 0.79 | EGFR (0.72) | EGFRERBB2GAKERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664028-A1 | QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | AstraZeneca AB (SE) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005026151-A1 | QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2005-03-24 | — | — | WO | disclosed |