SCHEMBL6017786

SCHEMBL6017786

CCc1cccc(C)c1CNc1cc(C(=O)NCCOC)cn2nc(C)nc12

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 7/20 0.51
CYP2C9 P11712 6/20 0.51
CYP2D6 P10635 3/20 0.51
CYP1A2 P05177 2/20 0.51
CYP2C19 P33261 2/20 0.51
MAPK14 Q16539 3/20 0.40
PDCD1 Q15116 1/20 0.39
CD274 Q9NZQ7 1/20 0.39
HPGD P15428 4/20 0.36
ALDH1A1 P00352 2/20 0.36
HSD17B10 Q99714 2/20 0.36
KDM4E B2RXH2 1/20 0.36
HTT P42858 1/20 0.36
KMT2A Q03164 2/20 0.36
ALPL P05186 1/20 0.35
GAA P10253 1/20 0.35
POLB P06746 1/20 0.34
CD38 P28907 1/20 0.34
KCNH2 Q12809 1/20 0.34
MEN1 O00255 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4662488 0.88 CYP3A4 (0.56) CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19
SCHEMBL4662008 0.85 CYP3A4 (0.57) CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19
SCHEMBL1812976 0.84 CYP3A4 (0.73) CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19
SCHEMBL5667817 0.83 CYP3A4 (0.54) CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19
SCHEMBL4662540 0.83 CYP3A4 (0.55) CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19
SCHEMBL4663671 0.81 CYP3A4 (0.47) CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19
SCHEMBL4663695 0.80 CYP3A4 (0.44) CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19
Hydrochloric Acid SCHEMBL4663702 0.80 CYP3A4 (0.43) CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19
SCHEMBL4663690 0.78 CYP3A4 (0.51) CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19
SCHEMBL4663733 0.77 CYP3A4 (0.48) CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1711498-A2 1,2,4-TRIAZOLO¬1,5-A|PYRIDINES AS GASTRIC ACID SECRETION INHIBITORS Altana Pharma AG (DE) 2006-10-18 EP disclosed
WO-2005070927-A2 1,2,4-TRIAZOLO[1,5-A] PYRIDINES AS GASTRIC ACID SECRETION INHIBITORS ALTANA PHARMA AG (DE) 2005-08-04 WO disclosed