Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.68 |
| ▸ | KDR | P35968 | 14/20 | 0.64 |
| ▸ | RET | P07949 | 12/20 | 0.64 |
| ▸ | KIF5B | P33176 | 10/20 | 0.64 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.61 |
| ▸ | EPHA2 | P29317 | 4/20 | 0.61 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.61 |
| ▸ | FLT1 | P17948 | 3/20 | 0.61 |
| ▸ | EPHB2 | P29323 | 3/20 | 0.60 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.60 |
| ▸ | EPHA4 | P54764 | 2/20 | 0.60 |
| ▸ | BTK | Q06187 | 2/20 | 0.60 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.60 |
| ▸ | GAK | O14976 | 1/20 | 0.60 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.60 |
| ▸ | STK10 | O94804 | 1/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.60 |
| ▸ | ABL1 | P00519 | 1/20 | 0.60 |
| ▸ | LCK | P06239 | 1/20 | 0.60 |
| ▸ | YES1 | P07947 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL907165 | 0.99 | EGFR (0.67) | EGFRKDRRETKIF5BERBB2 | |
| SCHEMBL30459542 | 0.96 | EGFR (0.70) | EGFRKDRRETKIF5BERBB2 | |
| SCHEMBL14843536 | 0.96 | EGFR (0.70) | EGFRKDRRETKIF5BERBB2 | |
| SCHEMBL29453257 | 0.96 | EGFR (0.70) | EGFRKDRRETKIF5BERBB2 | |
| Hydrochloric Acid SCHEMBL28257165 | 0.95 | EGFR (0.69) | EGFRKDRRETKIF5BERBB2 | |
| Trifluoroacetic Acid SCHEMBL907408 | 0.92 | EGFR (0.65) | EGFRKDRRETKIF5BERBB2 | |
| SCHEMBL12898759 | 0.89 | KDR (0.63) | EGFRKDRRETKIF5BERBB2 | |
| Hydrochloric Acid SCHEMBL907194 | 0.89 | KDR (0.62) | EGFRKDRRETKIF5BERBB2 | |
| SCHEMBL16938727 | 0.88 | EGFR (0.67) | EGFRKDRRETKIF5BERBB2 | |
| SCHEMBL17967495 | 0.87 | EGFR (0.69) | EGFRKDRRETKIF5BERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359332-B2 | Processes for the preparation of substituted quinazolines | SYMPHONY EVOLUTION, INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-9163006-B2 | — | — | 2015-10-20 | — | — | US | disclosed |
| EP-1521747-A4 | RECEPTOR-TYPE KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2006-10-11 | — | — | EP | disclosed |
| EP-1521747-A2 | RECEPTOR-TYPE KINASE MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2005-04-13 | — | — | EP | disclosed |
| WO-2004006846-A2 | RECEPTOR-TYPE KINASE MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2004-01-22 | — | — | WO | disclosed |