Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2173659 | 0.93 | GRM5 (0.37) | GRM5 | |
| SCHEMBL2173112 | 0.89 | GRM5 (0.40) | GRM5CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL2174683 | 0.79 | GRM5 (0.51) | GRM5 | |
| SCHEMBL4631174 | 0.74 | GRM5 (0.64) | GRM5 | |
| SCHEMBL1020277 | 0.69 | GRM5 (0.50) | GRM5 | |
| SCHEMBL4630595 | 0.69 | GRM5 (0.69) | GRM5 | |
| SCHEMBL2172122 | 0.67 | GRM5 (0.39) | GRM5 | |
| SCHEMBL2176710 | 0.67 | GRM5 (0.61) | GRM5 | |
| SCHEMBL2172650 | 0.66 | POLB (0.42) | CHRNB2CHRNA4CHRNB4CHRNA3CYP11B2 | |
| SCHEMBL1021159 | 0.65 | GRM5 (0.49) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636206-A1 | IMIDAZOLE DERIVATIVES AS GLUTMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004108701-A1 | IMIDAZOLE DERIVATIVES AS GLUTMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-12-16 | — | — | WO | disclosed |