Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | DHFR | P00374 | 1/20 | 0.52 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6026902 | 0.90 | NPC1 (0.64) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL6027050 | 0.85 | NPC1 (0.75) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL4438607 | 0.84 | NPC1 (0.66) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL6027810 | 0.83 | NPC1 (0.68) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL6027602 | 0.83 | NPC1 (0.68) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL29360828 | 0.83 | NPC1 (0.77) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL1101199 | 0.83 | NPC1 (0.77) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL27844033 | 0.82 | NPC1 (0.62) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL6027354 | 0.82 | NPC1 (0.62) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL6021966 | 0.82 | NPC1 (0.76) | NPC1RAB9AMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1075483-B1 | HYGROMYCIN A DERIVATIVES | PFIZER PROD INC (US) | 2003-12-03 | — | — | EP | claimed |
| EP-1077984-B1 | 2\"-DEOXY HYGROMYCIN DERIVATIVES | PFIZER PROD INC (US) | 2003-06-18 | — | — | EP | claimed |
| US-6342497-B1 | 2″-deoxy hygromycin derivatives | PFIZER INC | 2002-01-29 | — | — | US | claimed |
| US-6313100-B1 | ANTIBACTERIAL, ANTIPROTOZOA AGENTS | PFIZER INC | 2001-11-06 | — | — | US | claimed |
| EP-1658271-A1 | NOVEL 6-PHENYLPHENANTHRIDINES | ALTANA Pharma AG (DE) | 2006-05-24 | — | — | EP | disclosed |
| EP-1369490-B1 | Method of preparing a composition containing hygromycin A and epi-hygromycin | PFIZER PROD INC (US) | 2006-02-08 | — | — | EP | disclosed |
| WO-2005012253-A1 | NOVEL 6-PHENYLPHENANTHRIDINES | ALTANA PHARMA AG (DE) | 2005-02-10 | — | — | WO | disclosed |
| EP-1369490-A1 | Method of preparing a composition containing hygromycin A and epi-hygromycin | Pfizer Products Inc. (US) | 2003-12-10 | — | — | EP | disclosed |
| EP-1075483-B1 | HYGROMYCIN A DERIVATIVES | PFIZER PROD INC (US) | 2003-12-03 | — | — | EP | disclosed |
| US-20030157491-A1 | HarA polypeptides and nucleic acids, and related methods and uses thereof | MUELLER JOHN P (US) | 2003-08-21 | — | — | US | disclosed |
| EP-1077984-B1 | 2\"-DEOXY HYGROMYCIN DERIVATIVES | PFIZER PROD INC (US) | 2003-06-18 | — | — | EP | disclosed |
| EP-1227324-A2 | Har A polypeptides and nucleic acids and related methods and uses thereof | Pfizer Products Inc. (US) | 2002-07-31 | — | — | EP | disclosed |
| US-6342497-B1 | 2″-deoxy hygromycin derivatives | PFIZER INC | 2002-01-29 | — | — | US | disclosed |
| US-6313100-B1 | ANTIBACTERIAL, ANTIPROTOZOA AGENTS | PFIZER INC | 2001-11-06 | — | — | US | disclosed |