Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | AKT2 | P31751 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6021987 | 0.85 | CD274 (0.37) | CHRM2AKT1AKT2CD274NPC1 | |
| SCHEMBL5501520 | 0.84 | CHRM2 (0.43) | CHRM2AKT1AKT2CD274NPC1 | |
| SCHEMBL2639518 | 0.84 | NPC1 (0.45) | CHRM2AKT1AKT2CD274SIGMAR1 | |
| SCHEMBL2639950 | 0.77 | CHRM2 (0.37) | CHRM2AKT1AKT2CD274GAA | |
| SCHEMBL2639688 | 0.76 | POLB (0.44) | CHRM2AKT1AKT2CD274GAA | |
| SCHEMBL5412081 | 0.76 | CD274 (0.44) | AKT1AKT2CD274NPC1RAB9A | |
| SCHEMBL6022071 | 0.76 | GAA (0.46) | CHRM2AKT1AKT2CD274GAA | |
| SCHEMBL6022395 | 0.75 | EPHX2 (0.36) | CHRM2 | |
| SCHEMBL1303507 | 0.74 | CHRM2 (0.57) | CHRM2 | |
| SCHEMBL4695511 | 0.73 | PDCD1 (0.34) | CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1723114-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005087738-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2005-09-22 | — | — | WO | disclosed |