Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 16/20 | 0.77 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.77 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.77 |
| ▸ | HPGD | P15428 | 2/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.77 |
| ▸ | MEN1 | O00255 | 1/20 | 0.77 |
| ▸ | MLNR | O43193 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | MMP1 | P03956 | 1/20 | 0.77 |
| ▸ | MPO | P05164 | 1/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.77 |
| ▸ | GLA | P06280 | 1/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.77 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.77 |
| ▸ | MAPT | P10636 | 1/20 | 0.77 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.77 |
| ▸ | TSHR | P16473 | 1/20 | 0.77 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.77 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.77 |
| ▸ | APEX1 | P27695 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nimesulide SCHEMBL4796058 | 0.87 | CYP19A1 (1.00) | CYP19A1PTGS1PTGS2HPGDKDM4E | |
| Nimesulide SCHEMBL29393272 | 0.87 | CYP19A1 (1.00) | CYP19A1PTGS1PTGS2HPGDKDM4E | |
| Nimesulide SCHEMBL24882 | 0.87 | CYP19A1 (1.00) | CYP19A1PTGS1PTGS2HPGDKDM4E | |
| Nimesulide SCHEMBL3367702 | 0.86 | CYP19A1 (0.97) | CYP19A1PTGS1PTGS2HPGDKDM4E | |
| Nimesulide SCHEMBL3367706 | 0.86 | CYP19A1 (0.97) | CYP19A1PTGS1PTGS2HPGDKDM4E | |
| Nimesulide SCHEMBL25233223 | 0.86 | CYP19A1 (0.97) | CYP19A1PTGS1PTGS2HPGDKDM4E | |
| Nimesulide SCHEMBL3120335 | 0.86 | CYP19A1 (0.97) | CYP19A1PTGS1PTGS2HPGDKDM4E | |
| Nimesulide SCHEMBL10381405 | 0.86 | CYP19A1 (0.97) | CYP19A1PTGS1PTGS2HPGDKDM4E | |
| Nimesulide SCHEMBL11790433 | 0.86 | CYP19A1 (0.97) | CYP19A1PTGS1PTGS2HPGDKDM4E | |
| Nimesulide SCHEMBL29106069 | 0.86 | CYP19A1 (0.97) | CYP19A1PTGS1PTGS2HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363669-A2 | METHOD OF USING A CYCLOOXYGENASE-2 INHIBITOR AND SEX STEROIDS AS A COMBINATION THERAPY FOR THE TREATMENT AND PREVENTION OF DISMENORRHEA | Pharmacia Corporation (US) | 2003-11-26 | — | — | EP | claimed |
| WO-2002062391-A2 | METHOD OF USING A CYCLOOXYGENASE-2 INHIBITOR AND SEX STEROIDS AS A COMBINATION THERAPY FOR THE TREATMENT AND PREVENTION OF DISMENORRHEA | PHARMACIA CORPORATION (US) | 2002-08-15 | — | — | WO | claimed |
| US-7432261-B2 | Anti-inflammatory phosphonate compounds | GILEAD SCIENCES, INC. (US) | 2008-10-07 | — | — | US | disclosed |
| EP-1670417-A2 | COMPOSITIONS OF A CYCLOOXYGENASE-2 SELECTIVE INHIBITOR ADMINISTERED UNDER HYPOTHERMIC CONDITIONS FOR THE TREATMENT OF ISCHENIC MEDIATED CENTRAL NERVOUS SYSTEM DISORDERS OR INJURY | Pharmacia Corporation (US) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005037193-A2 | COMPOSITIONS OF A CYCLOOXYGENASE-2 SELECTIVE INHIBITOR ADMINISTERED UNDER HYPOTHERMIC CONDITIONS FOR THE TREATMENT OF ISCHEMIC MEDIATED CENTRAL NERVOUS SYSTEM DISORDERS OR INJURY | PHARMACIA CORPORATION (US) | 2005-04-28 | — | — | WO | disclosed |
| EP-1363669-A2 | METHOD OF USING A CYCLOOXYGENASE-2 INHIBITOR AND SEX STEROIDS AS A COMBINATION THERAPY FOR THE TREATMENT AND PREVENTION OF DISMENORRHEA | Pharmacia Corporation (US) | 2003-11-26 | — | — | EP | disclosed |
| WO-2002062391-A2 | METHOD OF USING A CYCLOOXYGENASE-2 INHIBITOR AND SEX STEROIDS AS A COMBINATION THERAPY FOR THE TREATMENT AND PREVENTION OF DISMENORRHEA | PHARMACIA CORPORATION (US) | 2002-08-15 | — | — | WO | disclosed |