Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.75 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.54 |
| ▸ | TSHR | P16473 | 5/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 7/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 6/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | STAT1 | P42224 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2320061 | 0.87 | SMN1; SMN2 (0.77) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1L3MBTL1 | |
| SCHEMBL11421007 | 0.85 | MEN1 (0.62) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1TSHR | |
| SCHEMBL3135286 | 0.84 | SMN1; SMN2 (0.82) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1L3MBTL1 | |
| SCHEMBL10916752 | 0.83 | SMN1; SMN2 (0.76) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1L3MBTL1 | |
| SCHEMBL21059156 | 0.82 | SMN1; SMN2 (0.66) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1L3MBTL1 | |
| SCHEMBL22822387 | 0.82 | SMN1; SMN2 (0.70) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1L3MBTL1 | |
| SCHEMBL7378894 | 0.81 | SMN1; SMN2 (0.68) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1L3MBTL1 | |
| SCHEMBL13506223 | 0.81 | SMN1; SMN2 (0.68) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1L3MBTL1 | |
| SCHEMBL3867996 | 0.81 | SMN1; SMN2 (0.68) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1L3MBTL1 | |
| SCHEMBL8057145 | 0.80 | SMN1; SMN2 (0.67) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685119-A1 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | Abbott Laboratories (US) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005049593-A2 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2005-06-02 | — | — | WO | disclosed |
| WO-2005049594-A1 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2005-06-02 | — | — | WO | disclosed |