Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 20/20 | 0.61 |
| ▸ | NR1H3 | Q13133 | 20/20 | 0.61 |
| ▸ | RXRA | P19793 | 1/20 | 0.61 |
| ▸ | PPARG | P37231 | 1/20 | 0.56 |
| ▸ | PPARD | Q03181 | 1/20 | 0.56 |
| ▸ | PPARA | Q07869 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1125384 | 0.91 | NR1H2 (0.73) | NR1H2NR1H3RXRAPPARGPPARD | |
| SCHEMBL3848629 | 0.84 | NR1H2 (0.65) | NR1H2NR1H3RXRAPPARGPPARD | |
| SCHEMBL1124254 | 0.82 | NR1H2 (0.80) | NR1H2NR1H3RXRAPPARGPPARD | |
| SCHEMBL1125201 | 0.81 | NR1H2 (0.56) | NR1H2NR1H3RXRAPPARGPPARD | |
| SCHEMBL1126131 | 0.81 | NR1H2 (0.71) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL1124742 | 0.78 | NR1H2 (0.80) | NR1H2NR1H3RXRAPPARGPPARD | |
| SCHEMBL1125259 | 0.77 | NR1H2 (0.60) | NR1H2NR1H3RXRAPPARGPPARD | |
| SCHEMBL1125457 | 0.76 | NR1H2 (0.72) | NR1H2NR1H3RXRAPPARGPPARD | |
| SCHEMBL1125490 | 0.76 | NR1H2 (1.00) | NR1H2NR1H3RXRAPPARGPPARD | |
| SCHEMBL1125361 | 0.75 | NR1H2 (0.56) | NR1H2NR1H3RXRAPPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692111-A2 | QUINOLINES USEFUL IN TREATING CARDIOVASCULAR DISEASE | Wyeth, A Corporation of the State of Delaware (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005058834-A2 | QUINOLINES USEFUL IN TREATING CARDIOVASCULAR DISEASE | WYETH (US) | 2005-06-30 | — | — | WO | disclosed |