Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 20/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.75 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8347972 | 0.95 | ELANE (0.80) | ELANECYP2C9ADRB1HTR1AHRH3 | |
| SCHEMBL392105 | 0.91 | ELANE (0.76) | ELANECYP2C9ADRB1HTR1AHRH3 | |
| SCHEMBL395799 | 0.89 | ELANE (0.73) | ELANECYP2C9ADRB1HTR1AHRH3 | |
| SCHEMBL394572 | 0.88 | ELANE (0.71) | ELANECYP2C9ADRB1HTR1AHRH3 | |
| SCHEMBL4449580 | 0.88 | ELANE (0.85) | ELANECYP2C9ADRB1HTR1AHRH3 | |
| SCHEMBL394085 | 0.88 | ELANE (0.85) | ELANECYP2C9ADRB1HTR1AHRH3 | |
| SCHEMBL394677 | 0.88 | ELANE (0.85) | ELANECYP2C9ADRB1HTR1AHRH3 | |
| SCHEMBL391816 | 0.86 | ELANE (1.00) | ELANECYP2C9ADRB1HTR1AHRH3 | |
| SCHEMBL395186 | 0.86 | ELANE (1.00) | ELANECYP2C9ADRB1HTR1AHRH3 | |
| SCHEMBL1243939 | 0.85 | ELANE (0.72) | ELANECYP2C9ADRB1HTR1AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1723121-A1 | 1,4-DIARYL-DIHYDROPYRIMIDIN-2-ONES AND THEIR USE AS HUMAN NEUTROPHIL ELASTASE INHIBITORS | Bayer HealthCare AG (DE) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005082864-A1 | 1,4-DIARYL-DIHYDROPYRIMIDIN-2-ONES AND THEIR USE AS HUMAN NEUTROPHIL ELASTASE INHIBITORS | BAYER HEALTHCARE AG (DE) | 2005-09-09 | — | — | WO | disclosed |