Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.44 |
| ▸ | CSF1R | P07333 | 3/20 | 0.44 |
| ▸ | KIT | P10721 | 2/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.44 |
| ▸ | FLT4 | P35916 | 5/20 | 0.44 |
| ▸ | FLT3 | P36888 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 9/20 | 0.40 |
| ▸ | KDR | P35968 | 8/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2053490 | 0.97 | PDGFRB (0.47) | AURKAPDGFRBCSF1RKITPDGFRA | |
| SCHEMBL2052693 | 0.89 | PDGFRB (0.53) | AURKAPDGFRBCSF1RKITPDGFRA | |
| SCHEMBL2050544 | 0.89 | AURKA (0.57) | AURKAPDGFRBCSF1RKITPDGFRA | |
| SCHEMBL5131119 | 0.88 | PDGFRB (0.44) | AURKAPDGFRBCSF1RKITPDGFRA | |
| SCHEMBL2049987 | 0.88 | AURKA (0.47) | AURKAPDGFRBCSF1RKITPDGFRA | |
| SCHEMBL6027640 | 0.87 | PDGFRB (0.51) | AURKAPDGFRBCSF1RKITPDGFRA | |
| SCHEMBL2052818 | 0.87 | AURKA (0.50) | AURKAPDGFRBCSF1RKITPDGFRA | |
| SCHEMBL2053015 | 0.86 | PDGFRB (0.49) | AURKAPDGFRBCSF1RKITPDGFRA | |
| SCHEMBL2050407 | 0.86 | CYP3A4 (0.48) | AURKAPDGFRBCSF1RKITPDGFRA | |
| SCHEMBL3429640 | 0.86 | FLT4 (0.49) | AURKAPDGFRBCSF1RKITPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613619-A1 | QUINAZOLINE DERIVATIVES FOR TREATMENT OF CANCER | AstraZeneca AB (SE) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004094410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-11-04 | — | — | WO | disclosed |