Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 4/20 | 0.52 |
| ▸ | CSF1R | P07333 | 2/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 12/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.48 |
| ▸ | FLT4 | P35916 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 3/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2053035 | 0.92 | PDGFRB (0.52) | PDGFRBCSF1RKITPDGFRAAURKA | |
| SCHEMBL2053244 | 0.91 | PDGFRB (0.56) | PDGFRBCSF1RKITPDGFRAAURKA | |
| SCHEMBL3431150 | 0.91 | PDGFRB (0.56) | PDGFRBCSF1RKITPDGFRAAURKA | |
| SCHEMBL2048171 | 0.90 | PDGFRB (0.53) | PDGFRBCSF1RKITPDGFRAAURKA | |
| SCHEMBL2052360 | 0.89 | PDGFRB (0.54) | PDGFRBCSF1RKITPDGFRAAURKA | |
| SCHEMBL3431835 | 0.88 | PDGFRB (0.55) | PDGFRBCSF1RKITPDGFRAAURKA | |
| SCHEMBL2031479 | 0.88 | PDGFRB (0.59) | PDGFRBCSF1RKITPDGFRAAURKA | |
| SCHEMBL2048212 | 0.88 | PDGFRB (0.54) | PDGFRBCSF1RKITPDGFRAAURKA | |
| SCHEMBL3427057 | 0.88 | PDGFRB (0.55) | PDGFRBCSF1RKITPDGFRAAURKA | |
| SCHEMBL5133135 | 0.87 | PDGFRB (0.53) | PDGFRBCSF1RKITPDGFRAAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613619-A1 | QUINAZOLINE DERIVATIVES FOR TREATMENT OF CANCER | AstraZeneca AB (SE) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004094410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-11-04 | — | — | WO | disclosed |