Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 6/20 | 0.56 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6082602 | 0.88 | CACNA2D1 (0.59) | CACNA2D1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6082653 | 0.88 | CACNA2D1 (0.59) | CACNA2D1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6025807 | 0.88 | CACNA2D1 (0.51) | CACNA2D1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6082444 | 0.86 | CACNA2D1 (0.55) | CACNA2D1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6082629 | 0.86 | CACNA2D1 (0.51) | CACNA2D1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6026332 | 0.85 | CACNA2D1 (0.73) | CACNA2D1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6081986 | 0.83 | HTT (0.52) | CACNA2D1HTTALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL6082598 | 0.81 | CACNA2D1 (0.52) | CACNA2D1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6082187 | 0.81 | CACNA2D1 (0.54) | CACNA2D1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6082948 | 0.78 | CACNA2D1 (0.56) | CACNA2D1PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539180-A4 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS INC (US) | 2006-08-30 | — | — | EP | disclosed |
| EP-1539180-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004018058-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2004-03-04 | — | — | WO | disclosed |