Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 14/20 | 0.66 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.57 |
| ▸ | FLT4 | P35916 | 4/20 | 0.57 |
| ▸ | FLT3 | P36888 | 3/20 | 0.57 |
| ▸ | CSF1R | P07333 | 2/20 | 0.56 |
| ▸ | KIT | P10721 | 1/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2050329 | 1.00 | AURKA (0.66) | AURKAAURKBPDGFRBFLT4FLT3 | |
| SCHEMBL2050773 | 1.00 | AURKA (0.66) | AURKAAURKBPDGFRBFLT4FLT3 | |
| SCHEMBL2053463 | 0.97 | AURKA (0.71) | AURKAAURKBPDGFRBFLT4FLT3 | |
| SCHEMBL2048431 | 0.95 | AURKA (0.73) | AURKAAURKBPDGFRBFLT4FLT3 | |
| SCHEMBL2052900 | 0.93 | AURKA (0.76) | AURKAAURKBPDGFRBFLT4FLT3 | |
| SCHEMBL3426897 | 0.93 | AURKA (0.76) | AURKAAURKBPDGFRBFLT4FLT3 | |
| SCHEMBL3427142 | 0.90 | AURKA (0.81) | AURKAAURKBPDGFRBFLT4FLT3 | |
| SCHEMBL3429296 | 0.90 | AURKA (0.81) | AURKAAURKBPDGFRBFLT4FLT3 | |
| SCHEMBL5133733 | 0.90 | AURKA (0.66) | AURKAAURKBPDGFRBFLT4FLT3 | |
| SCHEMBL5133569 | 0.90 | AURKA (0.66) | AURKAAURKBPDGFRBFLT4FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613619-A1 | QUINAZOLINE DERIVATIVES FOR TREATMENT OF CANCER | AstraZeneca AB (SE) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004094410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-11-04 | — | — | WO | disclosed |