Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 3/20 | 0.61 |
| ▸ | FLT4 | P35916 | 3/20 | 0.61 |
| ▸ | FLT3 | P36888 | 2/20 | 0.61 |
| ▸ | AURKA | O14965 | 14/20 | 0.57 |
| ▸ | KDR | P35968 | 5/20 | 0.53 |
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | BRAF | P15056 | 2/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | FLT1 | P17948 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2052933 | 0.94 | PDGFRB (0.62) | PDGFRBFLT4FLT3AURKAKDR | |
| SCHEMBL2053495 | 0.92 | KDR (0.64) | PDGFRBFLT4FLT3AURKAKDR | |
| SCHEMBL5131787 | 0.91 | PDGFRB (0.59) | PDGFRBFLT4FLT3AURKAKDR | |
| SCHEMBL3428895 | 0.90 | PDGFRB (0.58) | PDGFRBFLT4FLT3AURKAKDR | |
| SCHEMBL2049232 | 0.90 | AURKA (0.62) | PDGFRBFLT4FLT3AURKAKDR | |
| SCHEMBL2053145 | 0.87 | FLT3 (0.69) | PDGFRBFLT4FLT3AURKAKDR | |
| SCHEMBL5132484 | 0.86 | AURKA (0.67) | PDGFRBFLT4FLT3AURKAKDR | |
| SCHEMBL3432058 | 0.85 | AURKA (0.79) | PDGFRBFLT4FLT3AURKAKDR | |
| SCHEMBL5132487 | 0.85 | AURKA (0.67) | PDGFRBFLT4FLT3AURKAKDR | |
| SCHEMBL5133407 | 0.84 | FLT3 (0.62) | PDGFRBFLT4FLT3AURKAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613619-A1 | QUINAZOLINE DERIVATIVES FOR TREATMENT OF CANCER | AstraZeneca AB (SE) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004094410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-11-04 | — | — | WO | disclosed |