Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 5/20 | 0.54 |
| ▸ | FLT4 | P35916 | 5/20 | 0.54 |
| ▸ | FLT3 | P36888 | 3/20 | 0.54 |
| ▸ | CSF1R | P07333 | 3/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 7/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 5/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3431027 | 0.93 | PDGFRB (0.53) | PDGFRBFLT4FLT3CSF1RPDGFRA | |
| SCHEMBL2049819 | 0.91 | PDGFRB (0.64) | PDGFRBFLT4FLT3CSF1RPDGFRA | |
| SCHEMBL2052748 | 0.89 | PDGFRB (0.55) | PDGFRBFLT4FLT3CSF1RPDGFRA | |
| SCHEMBL2031479 | 0.88 | PDGFRB (0.59) | PDGFRBFLT4FLT3CSF1RPDGFRA | |
| SCHEMBL2053159 | 0.88 | PDGFRB (0.57) | PDGFRBFLT4FLT3CSF1RPDGFRA | |
| SCHEMBL2049575 | 0.88 | PDGFRB (0.57) | PDGFRBFLT4FLT3CSF1RPDGFRA | |
| SCHEMBL2050160 | 0.88 | PDGFRB (0.57) | PDGFRBFLT4FLT3CSF1RPDGFRA | |
| SCHEMBL3427484 | 0.88 | PDGFRB (0.52) | PDGFRBFLT4FLT3CSF1RPDGFRA | |
| Hydrochloric Acid SCHEMBL3427687 | 0.88 | PDGFRB (0.56) | PDGFRBFLT4FLT3CSF1RPDGFRA | |
| Hydrochloric Acid SCHEMBL3427279 | 0.88 | PDGFRB (0.56) | PDGFRBFLT4FLT3CSF1RPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613619-A1 | QUINAZOLINE DERIVATIVES FOR TREATMENT OF CANCER | AstraZeneca AB (SE) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004094410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-11-04 | — | — | WO | disclosed |