Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 12/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.52 |
| ▸ | CSF1R | P07333 | 3/20 | 0.52 |
| ▸ | KIT | P10721 | 2/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | FLT4 | P35916 | 5/20 | 0.48 |
| ▸ | FLT3 | P36888 | 4/20 | 0.48 |
| ▸ | EGFR | P00533 | 3/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.45 |
| ▸ | BRAF | P15056 | 2/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | CIT | O14578 | 1/20 | 0.41 |
| ▸ | MUSK | O15146 | 1/20 | 0.41 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.41 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | STK10 | O94804 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2049398 | 0.93 | AURKA (0.55) | AURKAAURKBPDGFRBCSF1RKIT | |
| SCHEMBL2051829 | 0.89 | AURKA (0.68) | AURKAAURKBPDGFRBCSF1RKIT | |
| SCHEMBL3431132 | 0.89 | AURKA (0.64) | AURKAAURKBPDGFRBCSF1RKIT | |
| SCHEMBL2051259 | 0.89 | CYP3A4 (0.54) | AURKAAURKBPDGFRBCSF1RKIT | |
| SCHEMBL5132955 | 0.89 | AURKA (0.55) | AURKAAURKBPDGFRBCSF1RKIT | |
| SCHEMBL5133680 | 0.88 | AURKA (0.58) | AURKAAURKBPDGFRBCSF1RKIT | |
| SCHEMBL2053257 | 0.88 | AURKA (0.68) | AURKAAURKBPDGFRBCSF1RKIT | |
| SCHEMBL2049366 | 0.88 | AURKA (0.64) | AURKAAURKBPDGFRBCSF1RKIT | |
| SCHEMBL5133450 | 0.87 | AURKA (0.54) | AURKAAURKBPDGFRBCSF1RKIT | |
| SCHEMBL2049575 | 0.87 | PDGFRB (0.57) | AURKAAURKBPDGFRBCSF1RKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613619-A1 | QUINAZOLINE DERIVATIVES FOR TREATMENT OF CANCER | AstraZeneca AB (SE) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004094410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-11-04 | — | — | WO | disclosed |