Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.36 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.35 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.35 |
| ▸ | ITGAL | P20701 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | SLC9A5 | Q14940 | 1/20 | 0.34 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6027573 | 0.79 | ATM (0.38) | ATMKEAP1SLC9A1SSTR4ITGB2 | |
| SCHEMBL18027909 | 0.75 | ITGB2 (0.41) | KEAP1SSTR4ITGB2ICAM1ITGAL | |
| SCHEMBL13091456 | 0.74 | SMN1; SMN2 (0.43) | KEAP1SMN1; SMN2DRD2DRD3 | |
| SCHEMBL31085324 | 0.72 | ATM (0.47) | ATMSLC9A1SSTR4MAPK1ITGB2 | |
| SCHEMBL29866456 | 0.72 | TSHR (0.71) | TSHRNPSR1GAASMN1; SMN2 | |
| SCHEMBL5392581 | 0.72 | ATM (0.47) | ATMSLC9A1SSTR4MAPK1ITGB2 | |
| SCHEMBL16303077 | 0.72 | TSHR (0.71) | TSHRNPSR1GAASMN1; SMN2 | |
| SCHEMBL5392565 | 0.72 | ATM (0.47) | ATMSLC9A1SSTR4MAPK1ITGB2 | |
| SCHEMBL31085320 | 0.72 | ATM (0.47) | ATMSLC9A1SSTR4MAPK1ITGB2 | |
| SCHEMBL30241060 | 0.72 | ATM (0.47) | ATMSLC9A1SSTR4MAPK1ITGB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1794997-B | 2,3,4, 5-tetrahydrobenzo [ f ] [1,4] oxazepine-5-carboxylic acid amide derivatives as gamma-secretase inhibitors for the treatment of alzheimer's disease | HOFFMANN LA ROCHE | 2010-05-12 | — | — | CN | disclosed |
| CN-1794997-A | 2,3,4, 5-tetrahydrobenzo [ f ] [1,4] oxazepine-5-carboxylic acid amide derivatives as gamma-secretase inhibitors for the treatment of alzheimer's disease | HOFFMANN LA ROCHE (CH) | 2006-06-28 | — | — | CN | disclosed |
| EP-1631296-A1 | 2,3,4,5-TETRAHYDROBENZO[F][1,4]OXAZEPINE-5-CARBOXYLIC ACID AMIDE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-08 | — | — | EP | disclosed |
| WO-2004100958-A1 | 2, 3, 4, 5-TETRAHYDROBENZO[F][1, 4]OXAZEPINE-5-CARBOXYLIC ACID AMIDE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER’S DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2004-11-25 | — | — | WO | disclosed |