Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.48 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.48 |
| ▸ | NR2E3 | Q9Y5X4 | 3/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6026276 | 0.90 | PTPN1 (0.52) | PTPN1PTPN2NR2E3SCN3ASCN9A | |
| SCHEMBL6027443 | 0.89 | NR2E3 (0.49) | PTPN1PTPN2NR2E3KDM4EMEN1 | |
| SCHEMBL6028360 | 0.87 | PTPN1 (0.62) | PTPN1PTPN2NR2E3SCN3ASCN9A | |
| SCHEMBL14305032 | 0.87 | PTPN1 (0.62) | PTPN1PTPN2NR2E3SCN3ASCN9A | |
| SCHEMBL6028790 | 0.87 | PTPN1 (0.62) | PTPN1PTPN2NR2E3SCN3ASCN9A | |
| SCHEMBL14311202 | 0.87 | PTPN1 (0.62) | PTPN1PTPN2NR2E3SCN3ASCN9A | |
| SCHEMBL6026306 | 0.87 | HPGD (0.56) | PTPN1PTPN2NR2E3NPY5RSCN3A | |
| SCHEMBL6026517 | 0.83 | MEN1 (0.52) | PTPN1PTPN2MEN1KMT2ANPC1 | |
| SCHEMBL6026099 | 0.82 | NAMPT (0.54) | PTPN1PTPN2SCN3ASCN9AALDH1A1 | |
| SCHEMBL6025801 | 0.82 | PTPN1 (0.50) | PTPN1PTPN2NR2E3SCN3ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613310-A1 | IMIDAZOLE DERIVATIVES FOR TREATMENT OF ALLERGIC AND HYPERPROLIFERATIVE DISORDERS | Avanir Pharmaceuticals (US) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004091610-A1 | IMIDAZOLE DERIVATIVES FOR TREATMENT OF ALLERGIC AND HYPERPROLIFERATIVE DISORDERS | AVANIR PHARMACEUTICALS (US) | 2004-10-28 | — | — | WO | disclosed |