Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.56 |
| ▸ | NOS3 | P29474 | 1/20 | 0.51 |
| ▸ | NOS1 | P29475 | 1/20 | 0.51 |
| ▸ | NOS2 | P35228 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | GNRHR | P30968 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | MGAM | O43451 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | SI | P14410 | 3/20 | 0.43 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL604385 | 0.82 | HRH4 (0.53) | HRH4NOS3NOS1NOS2MEN1 | |
| SCHEMBL602095 | 0.81 | HRH4 (0.57) | HRH4DRD3GNRHRMGAMGAA | |
| SCHEMBL602184 | 0.81 | HRH4 (0.80) | HRH4DRD3DRD2MGAMGAA | |
| SCHEMBL603789 | 0.79 | DRD3 (0.54) | HRH4DRD3GNRHRMGAMGAA | |
| SCHEMBL602177 | 0.78 | HRH4 (0.81) | HRH4DRD3DRD2MGAMGAA | |
| SCHEMBL604837 | 0.78 | HRH4 (0.66) | HRH4DRD3DRD2MGAMGAA | |
| SCHEMBL604153 | 0.74 | HRH4 (0.75) | HRH4DRD3DRD2 | |
| SCHEMBL602737 | 0.74 | HRH4 (0.48) | HRH4DRD3MGAMGAASI | |
| SCHEMBL602634 | 0.72 | HRH4 (0.69) | HRH4DRD3DRD2 | |
| SCHEMBL605157 | 0.72 | HRH4 (1.00) | HRH4DRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673348-A2 | BENZOIMIDAZOLE COMPOUNDS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005044807-A2 | BENZOIMIDAZOLE COMPOUNDS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-05-19 | — | — | WO | disclosed |