SCHEMBL6027701

SCHEMBL6027701

COc1c(C)cnc(Cn2ccc3c(Br)nc(Nc4ccccc4)nc32)c1C

nearest known ligand 0.55

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 15/20 0.55
TLR7 Q9NYK1 1/20 0.41
HSP90AB1 P08238 2/20 0.40
TRAP1 Q12931 2/20 0.40
HSP90B1 P14625 1/20 0.40
PTK2 Q05397 1/20 0.37
PDGFRB P09619 1/20 0.37
KDR P35968 1/20 0.37
CDK4 P11802 1/20 0.36
CCND1 P24385 1/20 0.36
CCND2 P30279 1/20 0.36
CCND3 P30281 1/20 0.36
WEE1 P30291 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3391730 0.81 HSP90AA1 (0.77) HSP90AA1TLR7HSP90AB1TRAP1HSP90B1
SCHEMBL6027699 0.79 HSP90AA1 (0.49) HSP90AA1TLR7HSP90AB1TRAP1HSP90B1
SCHEMBL6027695 0.79 HSP90AA1 (0.59) HSP90AA1TLR7HSP90AB1TRAP1HSP90B1
SCHEMBL3389600 0.71 HSP90AA1 (1.00) HSP90AA1HSP90AB1TRAP1HSP90B1
SCHEMBL3396845 0.70 HSP90AA1 (0.67) HSP90AA1TLR7HSP90AB1TRAP1HSP90B1
SCHEMBL5546339 0.69 HSP90AA1 (0.56) HSP90AA1HSP90AB1TRAP1HSP90B1
SCHEMBL13539445 0.69 HSP90AA1 (0.63) HSP90AA1TLR7HSP90AB1TRAP1HSP90B1
SCHEMBL313239 0.68 HSP90AA1 (0.64) HSP90AA1TLR7HSP90AB1TRAP1HSP90B1
SCHEMBL3389690 0.68 HSP90AA1 (0.61) HSP90AA1TLR7HSP90AB1TRAP1HSP90B1
SCHEMBL13539613 0.67 HSP90AA1 (0.56) HSP90AA1TLR7HSP90AB1TRAP1HSP90B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1670802-A2 NOVEL HETEROCYCLIC COMPOUNDS AS HSP90-INHIBITORS Conforma Therapeutic Corporation (US) 2006-06-21 EP disclosed
WO-2005028434-A2 NOVEL HETEROCYCLIC COMPOUNDS AS HSP90-INHIBITORS CONFORMA THERAPEUTICS CORPORATION (US) 2005-03-31 WO disclosed