Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | PLAU | P00749 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3395178 | 0.69 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1 | |
| SCHEMBL11556929 | 0.67 | KMT2A (0.32) | MEN1KMT2ALMNAELANE | |
| Hydrochloric Acid SCHEMBL11558888 | 0.66 | MEN1 (0.33) | MEN1KMT2ALMNAELANEALDH1A1 | |
| SCHEMBL3395737 | 0.64 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1 | |
| SCHEMBL3395599 | 0.64 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1 | |
| SCHEMBL28330033 | 0.63 | HCAR2 (0.39) | MEN1KMT2AALDH1A1MCL1 | |
| SCHEMBL14438199 | 0.62 | CCR1 (0.37) | LMNAHSP90AA1HSP90AB1 | |
| SCHEMBL28658089 | 0.61 | HSP90AA1 (0.39) | ALDH1A1HSP90AA1HSP90AB1 | |
| SCHEMBL1395393 | 0.60 | HSP90AB1 (0.46) | HSP90AA1HSP90AB1 | |
| Zinc Ion SCHEMBL10992139 | 0.58 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670802-A2 | NOVEL HETEROCYCLIC COMPOUNDS AS HSP90-INHIBITORS | Conforma Therapeutic Corporation (US) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005028434-A2 | NOVEL HETEROCYCLIC COMPOUNDS AS HSP90-INHIBITORS | CONFORMA THERAPEUTICS CORPORATION (US) | 2005-03-31 | — | — | WO | disclosed |