Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 14/20 | 0.52 |
| ▸ | CCKAR | P32238 | 1/20 | 0.42 |
| ▸ | CCKBR | P32239 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4435805 | 0.91 | SCN9A (0.52) | SCN9ACCKARCCKBRKMT2AL3MBTL1 | |
| SCHEMBL5547781 | 0.91 | SCN9A (0.52) | SCN9ACCKARCCKBRKMT2AL3MBTL1 | |
| SCHEMBL5026561 | 0.90 | SCN9A (0.49) | SCN9ACCKARCCKBRKMT2AL3MBTL1 | |
| SCHEMBL5621305 | 0.90 | SCN9A (0.49) | SCN9ACCKARCCKBRKMT2AL3MBTL1 | |
| SCHEMBL6178795 | 0.90 | SCN9A (0.51) | SCN9ACCKARCCKBRKMT2AL3MBTL1 | |
| SCHEMBL4433694 | 0.90 | SCN9A (0.51) | SCN9ACCKARCCKBRKMT2AL3MBTL1 | |
| SCHEMBL4705050 | 0.87 | SCN9A (0.64) | SCN9ACCKARCCKBRKMT2AL3MBTL1 | |
| SCHEMBL12345861 | 0.87 | SCN9A (0.64) | SCN9ACCKARCCKBRKMT2AL3MBTL1 | |
| SCHEMBL14019266 | 0.87 | SCN9A (0.64) | SCN9ACCKARCCKBRKMT2AL3MBTL1 | |
| SCHEMBL6026863 | 0.85 | SCN9A (0.45) | SCN9ACCKARCCKBRKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673347-A1 | SUBSTITUTED DIBENZO-AZEPINE AND BENZO-DIAZEPINE DERIVATIVES USEFUL AS GAMMA-SECRETASE INHIBITORS | F. Hoffman-la Roche AG (CH) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005040126-A1 | SUBSTITUTED DIBENZO-AZEPINE AND BENZO-DIAZEPINE DERIVATIVES USEFUL AS GAMMA-SECRETASE INHIBITORS | F. HOFFMAN-LA ROCHE AG (CH) | 2005-05-06 | — | — | WO | disclosed |